The first symptoms of rabies may be very similar to those of the flu and may last for days.

Later signs and symptoms may include:

• Fever
• Headache
• Nausea
• Vomiting
• Agitation
• Anxiety
• Confusion
• Hyperactivity
• Difficulty swallowing
• Excessive salivation
• Fear brought on by attempts to drink fluids because of difficulty swallowing water
• Fear brought on by air blown on the face
• Hallucinations
• Insomnia
• Partial paralysis

Seek immediate medical care if you're bitten by any animal, or exposed to an animal suspected of having rabies. Based on your injuries and the situation in which the exposure happened, you and your doctor can decide whether you should receive treatment to prevent rabies.

Even if you aren't sure whether you've been bitten, seek medical attention. For instance, a bat that flies into your room while you're sleeping may bite you without waking you. If you awake to find a bat in your room, assume you've been bitten. Also, if you find a bat near a person who can't report a bite, such as a small child or a person with a disability, assume that person has been bitten.

The rabies virus causes a rabies infection. The virus spreads through the saliva of infected animals. Infected animals can spread the virus by biting another animal or a person.

In rare cases, rabies can be spread when infected saliva gets into an open wound or the mucous membranes, such as the mouth or eyes. This could happen if an infected animal licked an open cut on your skin.

Animals that can transmit the rabies virus

Any mammal (an animal that suckles its young) can spread the rabies virus. The animals most likely to spread the rabies virus to people include:

Pets and farm animals

• Cats
• Cows
• Dogs
• Ferrets
• Goats
• Horses

Wild animals

• Bats
• Beavers
• Coyotes
• Foxes
• Monkeys
• Raccoons
• Skunks
• Woodchucks

In very rare cases, the virus has been spread to tissue and organ transplant recipients from an infected organ.

Factors that can increase your risk of rabies include:

• Traveling or living in developing countries where rabies is more common
• Activities that are likely to put you in contact with wild animals that may have rabies, such as exploring caves where bats live or camping without taking precautions to keep wild animals away from your campsite
• Working as a veterinarian
• Working in a laboratory with the rabies virus
• Wounds to the head or neck, which may help the rabies virus travel to your brain more quickly

To reduce your risk of coming in contact with rabid animals:

• Vaccinate your pets. Cats, dogs and ferrets can be vaccinated against rabies. Ask your veterinarian how often your pets should be vaccinated.
• Keep your pets confined. Keep your pets inside and supervise them when outside. This will help keep your pets from coming in contact with wild animals.
• Protect small pets from predators. Keep rabbits and other small pets, such as guinea pigs, inside or in protected cages so that they are safe from wild animals. These small pets can't be vaccinated against rabies.
• Report stray animals to local authorities. Call your local animal control officials or other local law enforcement to report stray dogs and cats.
• Don't approach wild animals. Wild animals with rabies may seem unafraid of people. It's not normal for a wild animal to be friendly with people, so stay away from any animal that seems unafraid.
• Keep bats out of your home. Seal any cracks and gaps where bats can enter your home. If you know you have bats in your home, work with a local expert to find ways to keep bats out.

• Consider the rabies vaccine if you're traveling or often around animals that may have rabies. If you're traveling to a country where rabies is common and you'll be there for an extended period of time, ask your doctor whether you should receive the rabies vaccine. This includes traveling to remote areas where medical care is difficult to find.

If you work as a veterinarian or work in a lab with the rabies virus, get the rabies vaccine.

At the time a potentially rabid animal bites you, there's no way to know whether the animal has transmitted the rabies virus to you. It's common not to find bite marks, too. Your doctor may order many tests to detect the rabies virus, but they may need to be repeated later to confirm whether you're carrying the virus. Your doctor will likely recommend treatment as soon as possible to prevent the rabies virus from infecting your body if there's a chance you may have been exposed to the rabies virus.

Once a rabies infection is established, there's no effective treatment. Though a small number of people have survived rabies, the disease usually causes death. For that reason, if you think you've been exposed to rabies, you must get a series of shots to prevent the infection from taking hold.

Treatment for people bitten by animals with rabies

If you've been bitten by an animal that is known to have rabies, you'll receive a series of shots to prevent the rabies virus from infecting you. If the animal that bit you can't be found, it may be safest to assume that the animal has rabies. But this will depend on several factors, such as the type of animal and the situation in which the bite occurred.

Rabies shots include:

• A fast-acting shot (rabies immune globulin) to prevent the virus from infecting you. This is given if you haven't had the rabies vaccine. This injection is given near the area where the animal bit you if possible, as soon as possible after the bite.
• A series of rabies vaccinations to help your body learn to identify and fight the rabies virus. Rabies vaccinations are given as injections in your arm. If you haven't previously had the rabies vaccines, you'll receive four injections over 14 days. If you have had the rabies vaccine, you'll have two injections over the first three days.

Determining whether the animal that bit you has rabies

In some cases, it's possible to determine whether the animal that bit you has rabies before beginning the series of rabies shots. That way, if it's determined the animal is healthy, you won't need the shots.

Procedures for determining whether an animal has rabies vary by situation. For instance:

• Pets and farm animals. Cats, dogs and ferrets that bite can be observed for 10 days to see if they show signs and symptoms of rabies. If the animal that bit you remains healthy during the observation period, then it doesn't have rabies and you won't need rabies shots.

  Other pets and farm animals are considered on a case-by-case basis. Talk to your doctor and local public health officials to determine whether you should receive rabies shots.

• Wild animals that can be caught. Wild animals that can be found and captured, such as a bat that came into your home, can be killed and tested for rabies. Tests on the animal's brain may reveal the rabies virus. If the animal doesn't have rabies, you won't need the shots.
• Animals that can't be found. If the animal that bit you can't be found, discuss the situation with your doctor and the local health department. In certain cases, it may be safest to assume that the animal had rabies and proceed with the rabies shots. In other cases, it may be unlikely that the animal that bit you had rabies and it may be determined that rabies shots aren't necessary.

If an animal bites you, seek medical attention for the wound. Also tell the doctor about the circumstances of your injury. The doctor will ask:

• What animal bit you?
• Was it a wild animal or a pet?
• If it was a pet, do you know who owns the pet? Was it vaccinated?
• Can you describe the animal's behavior before it bit you? Was the animal provoked?
• Were you able to capture or kill the animal after it bit you?

What you can do in the meantime

Wash your wound gently and thoroughly with soap and generous amounts of water. This may help wash away the virus.

If the animal that bit you can be contained or captured without causing more injury, do so. Do not kill the animal with a blow or a shot to the head, as the resulting injuries may make it difficult to perform laboratory tests to determine whether the animal has rabies.

Tell your doctor that you have captured the animal that bit you. Your doctor may then contact the local health department to determine what to do with the animal.