Dementia is a term used to describe a group of symptoms affecting memory, thinking and social abilities. In people who have dementia, the symptoms interfere with their daily lives. Dementia isn't one specific disease. Several diseases can cause dementia.
Dementia generally involves memory loss. It's often one of the early symptoms of the condition. But having memory loss alone doesn't mean you have dementia. Memory loss can have different causes.
Alzheimer's disease is the most common cause of dementia in older adults, but there are other causes of dementia. Depending on the cause, some dementia symptoms might be reversible.
Dementia symptoms vary depending on the cause. Common symptoms include:
See a health care professional if you or a loved one has memory problems or other dementia symptoms. It's important to determine the cause. Some medical conditions that cause dementia symptoms can be treated.
Dementia is caused by damage to or loss of nerve cells and their connections in the brain. The symptoms depend on the area of the brain that's damaged. Dementia can affect people differently.
Dementias are often grouped by what they have in common. They may be grouped by the protein or proteins deposited in the brain or by the part of the brain that's affected. Also, some diseases have symptoms like those of dementia. And some medicines can cause a reaction that includes dementia symptoms. Not getting enough of certain vitamins or minerals also can cause dementia symptoms. When this occurs, dementia symptoms may improve with treatment.
Dementias that are progressive get worse over time. Types of dementias that worsen and aren't reversible include:
Alzheimer's disease. This is the most common cause of dementia.
Although not all causes of Alzheimer's disease are known, experts do know that a small percentage are related to changes in three genes. These gene changes can be passed down from parent to child. While several genes are probably involved in Alzheimer's disease, one important gene that increases risk is apolipoprotein E4 (APOE).
People with Alzheimer's disease have plaques and tangles in their brains. Plaques are clumps of a protein called beta-amyloid. Tangles are fibrous masses made up of tau protein. It's thought that these clumps damage healthy brain cells and the fibers connecting them.
Vascular dementia. This type of dementia is caused by damage to the vessels that supply blood to the brain. Blood vessel problems can cause stroke or affect the brain in other ways, such as by damaging the fibers in the white matter of the brain.
The most common symptoms of vascular dementia include problems with problem-solving, slowed thinking, and loss of focus and organization. These tend to be more noticeable than memory loss.
Lewy body dementia. Lewy bodies are balloonlike clumps of protein. They have been found in the brains of people with Lewy body dementia, Alzheimer's disease and Parkinson's disease. Lewy body dementia is one of the more common types of dementia.
Common symptoms include acting out dreams in sleep and seeing things that aren't there, known as visual hallucinations. Symptoms also include problems with focus and attention. Other signs include uncoordinated or slow movement, tremors, and stiffness, known as parkinsonism.
Traumatic brain injury (TBI). This condition is most often caused by repetitive head trauma. Boxers, football players or soldiers might develop TBI.
Dementia symptoms depend on the part of the brain that's injured. TBI can cause depression, explosiveness, memory loss and impaired speech. TBI also may cause slow movement, tremors and stiffness. Symptoms might not appear until years after the trauma.
Creutzfeldt-Jakob disease. This rare brain disorder usually occurs in people without known risk factors. This condition might be due to deposits of infectious proteins called prions. Symptoms of this fatal condition usually appear after age 60.
Creutzfeldt-Jakob disease usually has no known cause but it can be passed down from a parent. It also may be caused by exposure to diseased brain or nervous system tissue, such as from a cornea transplant.
Some causes of dementia-like symptoms can be reversed with treatment. They include:
Many factors can eventually contribute to dementia. Some factors, such as age, can't be changed. You can address other factors to reduce your risk.
You might be able to control the following risk factors for dementia.
Medicines that can worsen memory. These include sleep aids that contain diphenhydramine (Benadryl) and medicines to treat urinary urgency such as oxybutynin (Ditropan XL).
Also limit sedatives and sleeping tablets. Talk to a health care professional about whether any of the medicines you take might make your memory worse.
Dementia can affect many body systems and, therefore, the ability to function. Dementia can lead to:
There's no sure way to prevent dementia, but there are steps you can take that might help. More research is needed, but it might help to do the following:
Get enough vitamins. Some research suggests that people with low levels of vitamin D in their blood are more likely to develop Alzheimer's disease and other forms of dementia. You can increase your vitamin D levels with certain foods, supplements and sun exposure.
More study is needed before an increase in vitamin D intake is recommended for preventing dementia. But it's a good idea to make sure you get adequate vitamin D. Taking a daily B-complex vitamin and vitamin C also might help.
Manage cardiovascular risk factors. Treat high blood pressure, high cholesterol and diabetes. Pay attention to your levels of LDL cholesterol and get treatment if the levels are too high. High levels of LDL in middle age raises the risk of dementia. Lose weight if you're overweight.
High blood pressure might lead to a higher risk of some types of dementia. More research is needed to determine whether treating high blood pressure may reduce the risk of dementia.
To diagnose the cause of dementia, a health care professional must recognize the pattern of loss of skills and function. The care professional also determines what the person is still able to do. More recently, biomarkers have become available to make a more accurate diagnosis of Alzheimer's disease.
A health care professional reviews your medical history and symptoms and conducts a physical exam. Someone who is close to you may be asked about your symptoms as well.
No single test can diagnose dementia. You'll likely need a number of tests that can help pinpoint the problem.
These tests evaluate your thinking ability. A number of tests measure thinking skills, such as memory, orientation, reasoning and judgment, language skills, and attention.
Your memory, language skills, visual perception, attention, problem-solving skills, movement, senses, balance, reflexes and other areas are evaluated.
Simple blood tests can detect physical problems that can affect brain function, such as too little vitamin B-12 in the body or an underactive thyroid gland. Sometimes the spinal fluid is examined for infection, for inflammation or for markers of some degenerative diseases.
A mental health professional can determine whether depression or another mental health condition is contributing to your symptoms.
Most types of dementia can't be cured, but there are ways to manage your symptoms.
The following are used to temporarily improve dementia symptoms.
Cholinesterase inhibitors. These medicines work by boosting levels of a chemical messenger involved in memory and judgment. They include donepezil (Aricept, Adlarity), rivastigmine (Exelon) and galantamine (Razadyne ER).
Although primarily used to treat Alzheimer's disease, these medicines also might be prescribed for other dementias. They might be prescribed for people with vascular dementia, Parkinson's disease dementia and Lewy body dementia.
Side effects can include nausea, vomiting and diarrhea. Other possible side effects include slowed heart rate, fainting and sleep problems.
Memantine. Memantine (Namenda) works by regulating the activity of glutamate. Glutamate is another chemical messenger involved in brain functions such as learning and memory. Memantine is sometimes prescribed with a cholinesterase inhibitor.
A common side effect of memantine is dizziness.
The U.S. Food and Drug Administration (FDA) has approved lecanemab (Leqembi) and donanemab (Kisunla) for people with mild Alzheimer's disease and mild cognitive impairment due to Alzheimer's disease.
Clinical trials found that the medicines slowed declines in thinking and functioning in people with early Alzheimer's disease. The medicines prevent amyloid plaques in the brain from clumping.
Lecanemab is given as an IV infusion every two weeks. Side effects of lecanemab include infusion-related reactions such as fever, flu-like symptoms, nausea, vomiting, dizziness, changes in heart rate and shortness of breath.
Donanemab is given as an IV infusion every four weeks. Side effects of the medicine may include flu-like symptoms, nausea, vomiting, headache and changes in blood pressure. Rarely, donanemab can cause a life-threatening allergic reaction and swelling.
Also, people taking lecanemab or donanemab may have swelling in the brain or may get small bleeds in the brain. Rarely, brain swelling can be serious enough to cause seizures and other symptoms. Also in rare instances, bleeding in the brain can cause death. The FDA recommends getting a brain MRI before starting treatment. The FDA also recommends periodic brain MRIs during treatment for symptoms of brain swelling or bleeding.
People who carry a certain form of a gene known as APOE e4 appear to have a higher risk of these serious complications. The FDA recommends testing for this gene before starting treatment.
If you take a blood thinner or have other risk factors for brain bleeding, talk to your healthcare professional before taking lecanemab or donanemab. Blood-thinning medicines may increase the risk of bleeds in the brain.
More research is being done on the potential risks of taking lecanemab and donanemab. Other research is looking at how effective the medicines may be for people at risk of Alzheimer's disease, including people who have a first-degree relative, such as a parent or sibling, with the disease.
Several dementia symptoms and behavior problems might be treated initially with therapies other than medicine. These may include:
Dementia symptoms and behavior problems get worse over time. Caregivers and care partners might try the following suggestions:
Encourage exercise. The main benefits of exercise in people with dementia include improved strength, balance and cardiovascular health. Exercise also might help with symptoms such as restlessness. There is growing evidence that exercise also protects the brain from dementia, especially when combined with a healthy diet and treatment of risk factors for cardiovascular disease.
Some research also shows that physical activity might slow the progression of impaired thinking in people with Alzheimer's disease. It also can lessen symptoms of depression.
Establish a nighttime routine. Behavior is often worse at night. Try to establish going-to-bed routines. Aim for a calming routine away from the noise of television, meal cleanup and active family members. Leave night lights on in the bedroom, hall and bathroom to prevent disorientation.
Limiting caffeine, discouraging napping and offering opportunities for exercise during the day might ease nighttime restlessness.
Plan for the future. Develop a plan while your loved one is still able to participate. The plan can state goals for future care. Support groups, legal advisers, family members and others might be able to help.
You'll also need to consider financial and legal issues, safety and daily living concerns, and long-term care options.
Several dietary supplements, herbal remedies and therapies have been studied for people with dementia. But there's no convincing evidence that these treatments are effective.
Use caution when considering taking dietary supplements, vitamins or herbal remedies, especially if you're taking other medicines. Supplements, vitamins and herbs aren't regulated. Claims about their benefits aren't always based on scientific research.
While some studies suggest that vitamin E supplements may be helpful for Alzheimer's disease, study results have been mixed. Also, high doses of vitamin E can pose risks. Taking vitamin E supplements is generally not recommended. However, including foods high in vitamin E, such as nuts, in your diet is recommended.
The following techniques may help reduce agitation and promote relaxation in people with dementia.
After being diagnosed with dementia, you'll need to consider many details to prepare you and your family members to deal with the condition.
Here are some suggestions you can try to help yourself cope with the disease:
You can help a person cope with the disease by listening. Offer reassurance that the person can enjoy life. Be supportive and positive, and do your best to help the person retain dignity and self-respect.
Providing care for someone with dementia is physically and emotionally demanding. You might feel angry, guilty, frustrated or worried. Grief and social isolation are common. If you're a caregiver or care partner for someone with dementia:
Most likely, you'll first see a health care professional if you have concerns about dementia. Or you might be referred to a doctor trained in nervous system conditions, known as a neurologist.
Here's some information to help you get ready for your appointment.
When you make the appointment, ask if there's anything that needs to be done in advance, such as fasting before certain tests. Make a list of:
Even in the early stages of dementia, it's good to take a family member, friend or caregiver along to help you remember the information you're given.
For dementia, basic questions to ask a health care professional include:
Don't hesitate to ask other questions.
You're likely to be asked questions such as: